E noho ma luna o nā ʻano o ka honua i ka meaʻai, ka mahiʻai, ka ʻenehana ʻenehana a me ka hoʻopukapuka kālā me nā nūhou a me ka nānā ʻana o ka ʻoihana.
I kēia manawa, hana pinepine ʻia nā protein recombinant e nā microorganisms i loko o nā bioreactors kila nui. Akā, hiki i nā ʻinikena ke lilo i mea akamai a ʻoi aku ka maikaʻi, wahi a Antwerp-based startup FlyBlast, nāna i hoʻololi genetically i nā lele koa ʻeleʻele e hana i ka insulin a me nā protein waiwai ʻē aʻe.
Akā, aia paha nā pilikia i ka hoʻolālā mua o ka ʻoihana e ʻimi ana i ka ʻoihana ʻiʻo moʻomeheu a me ke kālā?
Ua loaʻa ʻo AgFunderNews (AFN) me ka mea hoʻokumu a me CEO Johan Jacobs (JJ) ma ka Future Food Tech Summit ma Lākana e aʻo hou aku…
DD: Ma FlyBlast, ua hoʻololi maoli mākou i ka lele koa ʻeleʻele e hana i ka insulin kanaka a me nā protein recombinant ʻē aʻe, a me nā kumu ulu i hoʻolālā ʻia no ka ulu ʻana i ka ʻiʻo (me ka hoʻohana ʻana i kēia mau protein pipiʻi i ka media moʻomeheu cell).
ʻO nā molekule e like me ka insulin, transferrin, IGF1, FGF2 a me EGF no 85% o ke kumukūʻai o ka moʻomeheu moʻomeheu. Ma ka hana nui ʻana i kēia mau biomolecules i nā keʻena bioconversion insect, hiki iā mākou ke hōʻemi i kā lākou kumukūʻai ma 95% a lanakila i kēia bottleneck.
ʻO ka pōmaikaʻi nui loa o nā lele koa ʻeleʻele [ma luna o nā microorganism i hoʻololi ʻia e like me ke ʻano o ka hana ʻana i ia mau protein] ʻo ia ka hiki iā ʻoe ke ulu i nā lele koa ʻeleʻele ma ke ʻano a me ke kumu kūʻai haʻahaʻa no ka mea ua hoʻonui ka ʻoihana holoʻokoʻa i ka bioconversion o nā huahana i nā protein nalo. a me nā lipids. Ke hoʻokiʻekiʻe nei mākou i ka pae o ka ʻenehana a me ka loaʻa kālā no ka mea kiʻekiʻe loa ka waiwai o kēia mau molekala.
ʻOkoʻa loa ke kumu kūʻai [no ka hōʻike ʻana i ka insulin i nā lele koa ʻeleʻele] mai [ke kumu kūʻai o ka fermentation pololei me ka hoʻohana ʻana i nā microorganisms], a ua uhi ʻia ke kumukūʻai nui e nā huahana insect maʻamau. ʻO ia wale nō ka loaʻa kālā ma luna o nā mea a pau. Akā, pono ʻoe e noʻonoʻo ʻo nā molekala a mākou e ʻimi nei he mau protein holoholona. ʻOi aku ka maʻalahi o ka hana ʻana i nā molekala holoholona i nā holoholona ma mua o ka hū a i ʻole bacteria.
No ka laʻana, ma ka haʻawina kūpono ua nānā mua mākou inā loaʻa i nā inike ke ala e like me ka insulin. ʻAe ka pane. Ua like loa ka mole mole me ka insulin kanaka a moa paha, no laila, ʻoi aku ka maʻalahi o ka noi ʻana i nā iniseti e hana i ka insulin kanaka ma mua o ka noi ʻana i ka bacteria a mea kanu paha, ʻaʻohe o kēia ala.
JJ: Ke nānā aku nei mākou i ka ʻiʻo moʻomeheu, ʻo ia kahi mākeke pono e hoʻomohala ʻia, no laila aia nā pilikia. Akā, ʻoiai ʻelua o kaʻu mau mea hoʻokumu i hele mai i kēlā mākeke (ua hana kekahi mau lālā o ka hui FlyBlast ma ka Antwerp-based artificial fat startup Peace of Meat, i hoʻopau ʻia e kāna mea nona Steakholder Foods i ka makahiki i hala), manaʻo mākou ua loaʻa iā mākou nā mākau. e hana i keia. ʻO ia kekahi o nā kī.
Loaʻa ka ʻiʻo moʻomeheu. E hiki mai ana. ʻO ka nīnau i ka wā hea, a he nīnau koʻikoʻi kēia no kā mākou mea hoʻopukapuka, no ka mea, pono lākou i ka loaʻa kālā i kahi manawa kūpono. No laila ke nānā nei mākou i nā mākeke ʻē aʻe. Ua koho mākou i ka insulin i kā mākou huahana mua no ka mea ua maopopo ka mākeke no kahi pani. ʻO ia ka insulin kanaka, maʻalahi, hiki ke hoʻonui ʻia, no laila aia kahi mākeke holoʻokoʻa no ka maʻi diabetes.
Akā, ʻo ka mea nui, ʻo kā mākou paepae ʻenehana he paepae maikaʻi loa… Ma kā mākou paepae ʻenehana, hiki iā mākou ke hana i ka hapa nui o nā molekala holoholona, nā protein, a me nā enzymes.
Hāʻawi mākou i ʻelua ʻano o nā lawelawe hoʻomaikaʻi genetic: hoʻokomo mākou i nā genes hou loa i loko o ka DNA o ka lele koa ʻeleʻele, e ʻae iā ia e hōʻike i nā molekala i loaʻa ʻole i kēia ʻano, e like me ka insulin kanaka. Akā, hiki iā mākou ke hōʻike nui a hoʻopaʻa paha i nā genes i loaʻa i loko o ka DNA ʻano hihiu e hoʻololi i nā waiwai e like me ka protein content, amino acid profile, a i ʻole ka hoʻohui ʻana i ka waikawa momona (ma o nā ʻaelike laikini me nā mea mahiʻai / mea hoʻoponopono.
DD: He nīnau maikaʻi loa kēlā, akā aia ʻelua o koʻu mau hoa hoʻokumu i ka ʻoihana ʻiʻo moʻomeheu, a ke manaʻoʻiʻo nei lākou ʻo [ka ʻimi ʻana i nā mea moʻomeheu cell cheaper e like me ka insulin] ka pilikia nui loa i ka ʻoihana, a ʻo ka ʻoihana pū kekahi. hopena nui i ke aniau.
ʻOiaʻiʻo, ke nānā nei mākou i ka mākeke lāʻau kanaka a me ka mākeke diabetes, akā pono mākou i kahi moku nui no ia mea no ka mea ma ke ʻano o ka loaʻa ʻana o ka ʻae hoʻoponopono, pono ʻoe i $10 miliona e hana i ka pepa, a laila pono ʻoe e hana. ʻoiaʻiʻo, loaʻa iā ʻoe ka molekala kūpono ma ka maʻemaʻe kūpono, a pēlā aku. E hana mākou i kekahi mau ʻanuʻu, a hiki i kahi manawa o ka hōʻoia, hiki iā mākou ke hoʻonui i ke kālā no ka mākeke biopharma.
J: E pili ana i ka scaling. Ua holo au i kahi ʻoihana mahiʻai insect [Millibeter, i loaʻa e [now defunct] AgriProtein i 2019] no 10 mau makahiki. No laila, ua nānā mākou i nā mea ʻokoʻa like ʻole, a ʻo ke kī ʻo ke ʻano o ka hoʻonui ʻana i ka hana me ka hilinaʻi a me ka liʻiliʻi, a nui nā hui i hoʻopau me nā lele koa ʻeleʻele a i ʻole mealworms. ʻAe, ʻoiaʻiʻo, hiki iā ʻoe ke ulu i nā nalo hua, akā paʻakikī maoli ka ulu ʻana iā lākou i nā mea nui ma ke ala haʻahaʻa a hilinaʻi hoʻi, a hiki i kekahi mau mea kanu ke hoʻohua i 10 tons biomass insect i ka lā.
JJ: No laila, hiki ke hoʻohana ʻia i nā mea ʻokoʻa ʻē aʻe, nā pūmua inika, nā lipid inika, a me nā mea ʻē aʻe, i ke kaulahao waiwai maʻamau, akā ma kekahi mau wahi, no ka mea he huahana genetically modified, ʻaʻole ia e ʻae ʻia i hānai holoholona.
Eia nō naʻe, nui nā noi ʻenehana ma waho o ke kaulahao meaʻai hiki ke hoʻohana i nā protein a me nā lipid. No ka laʻana, inā ʻoe e hana ana i ka ʻaila ʻenehana ma kahi pālākiō ʻoihana, ʻaʻole ia he mea nui inā no ka lipid mai kahi kumu hoʻololi genetically.
No ka manure [insect excrement], pono mākou e makaʻala i ka lawe ʻana iā ia i ke kula no ka mea aia i loko o nā ʻano GMO, no laila mākou e pyrolyze i biochar.
DD: I loko o hoʻokahi makahiki… ua loaʻa iā mākou kahi laina hānau paʻa e hōʻike ana i ka insulin kanaka i nā hua kiʻekiʻe loa. I kēia manawa pono mākou e unuhi i nā molekala a hāʻawi i nā laʻana i kā mākou mea kūʻai aku, a laila e hana pū me nā mea kūʻai aku i nā molekala e pono ai lākou.
Ka manawa hoʻouna: Dec-25-2024