Hlala uphezulu kwiintsingiselo zehlabathi kukutya, kwezolimo, kwitekhnoloji yemozulu kunye notyalo-mali ngeendaba eziphambili zeshishini kunye nohlalutyo.
Okwangoku, iiproteni eziphinda zidityaniswe ngokuqhelekileyo ziveliswa zii-microorganisms kwi-bioreactors yensimbi enkulu. Kodwa izinambuzane zinokuba krelekrele, iinginginya ezinoqoqosho ngakumbi, utshilo u-Antwerp-based startup FlyBlast, eguqula ngokwemfuza iimpukane zejoni elimnyama ukuvelisa i-insulin kunye nezinye iiproteni ezixabisekileyo.
Kodwa ngaba kukho imingcipheko kwisicwangciso sokuqala senkampani sokujolisa kumzi mveliso wenyama okhuliswe yimali esakhulayo?
I-AgFunderNews (AFN) ibambene nomseki kunye ne-CEO uJohan Jacobs (JJ) kwiFuture Food Tech Summit eLondon ukufunda ngakumbi…
I-DD: Kwi-FlyBlast, siye saguqula imfuza impukane yejoni elimnyama ukuze ivelise i-insulin yabantu kunye nezinye iiprotheni eziphinda ziphinde zibuyele, kunye nezinto zokukhula ezilungiselelwe ngokukodwa ukukhulisa inyama (ukusebenzisa ezi proteni ezibizayo kwimidiya yenkcubeko yeseli).
Iimolekyuli ezifana ne-insulin, i-transferrin, i-IGF1, i-FGF2 kunye ne-EGF i-akhawunti ye-85% yeendleko zenkcubeko yenkcubeko. Ngobuninzi bokuvelisa ezi biomolecules kwiindawo zezinambuzane ze-bioconversion, sinokunciphisa iindleko zabo nge-95% kwaye soyise le bhotile.
Inzuzo enkulu yeempukane zejoni elimnyama [ngaphezu kwee-microorganisms eziguqulwe ngokwemfuza njengendlela yokuvelisa iiprotheni ezinjalo] kukuba unokukhulisa iimpukane zejoni elimnyama kwinqanaba kwaye ngexabiso eliphantsi kuba ishishini lonke liye lanyusa i-bioconversion ye-by-products kwiiprotheni zezinambuzane. kunye ne-lipids. Siphakamisa nje inqanaba letekhnoloji kunye nenzuzo kuba ixabiso lezi molekyuli liphezulu kakhulu.
Ixabiso lenkunzi [lokuvakalisa i-insulin kwiimpukane zejoni elimnyama] lahluke ngokupheleleyo [kwixabiso lokuvundiswa ngokuchanekileyo kusetyenziswa iintsholongwane eziziintsholongwane], kwaye iindleko zenkunzi zihlawulwa ngeemveliso zezinambuzane eziqhelekileyo. Yenye nje indlela yengeniso phezu kwayo yonke loo nto. Kodwa kuya kufuneka uqwalasele ukuba iimolekyuli esijolise kuzo ziiproteni zezilwanyana ezithile. Kulula kakhulu ukuvelisa iimolekyuli zezilwanyana kwizilwanyana kunegwele okanye iibhaktheriya.
Umzekelo, kuphononongo olunokwenzeka siqale sajonga ukuba ingaba izinambuzane zinendlela efana ne-insulin na. Impendulo nguewe. I-molecule yezinambuzane ifana kakhulu ne-insulin yabantu okanye yenkukhu, ngoko ke ukucela izinambuzane ukuba zivelise i-insulin yabantu kulula kakhulu kunokubuza ibhaktheriya okanye izityalo, ezingenalo le ndlela.
JJ: Sigxile kwinyama ekhutshiweyo, eyimarike ekusafuneka iphuhliswe, ngoko ke kukho imingcipheko. Kodwa ekubeni ababini babaseki bam bevela kuloo marike (amalungu amaninzi eqela leFlyBlast asebenze kwi-Antwerp-based fat facial startup Peace of Meat, eyapheliswa ngumnini wayo iSteakholder Foods kulo nyaka uphelileyo), sikholelwa ukuba sinazo izakhono. ukwenza oku kwenzeke. Eso sesinye sezitshixo.
Inyama ekhulisiwe ekugqibeleni iya kufumaneka. Ngokuqinisekileyo kuya kwenzeka. Umbuzo kukuba nini, kwaye lo ngumbuzo obaluleke kakhulu kubatyali-mali bethu, kuba bafuna inzuzo ngexesha elifanelekileyo. Ngoko sijonge kwezinye iimarike. Sakhetha i-insulin njengemveliso yethu yokuqala kuba imarike yokutshintsha yayicacile. Yi-insulin yabantu, ingabizi kakhulu, iyancipha, ngoko kukho intengiso epheleleyo yesifo seswekile.
Kodwa eneneni, iqonga lethu letekhnoloji liqonga elikhulu… Kwiqonga lethu letekhnoloji, sinokuvelisa uninzi lweemolekyuli ezisekelwe kwizilwanyana, iiproteni, kunye neeenzymes.
Sinikezela ngeendlela ezimbini zeenkonzo zokuphucula imfuzo: sazisa ufuzo olutsha ngokupheleleyo kwiDNA yempukane yejoni elimnyama, siyivumela ukuba iveze iimolekyuli ezingekho ngokwendalo kolu didi, njenge-insulin yomntu. Kodwa sinokuphinda sicinezele okanye sicinezele ijene ekhoyo kwi-wild-type ye-DNA ukuguqula iimpawu ezifana nomxholo weprotheyini, iprofayili ye-amino acid, okanye ukubunjwa kwe-asidi enamafutha (ngezivumelwano zelayisensi kunye namafama ezinambuzane / abaprosesa).
DD: Ngumbuzo olungileyo ngenene lowo, kodwa ababini babaseki bam bakwishishini lenyama ekhulisiweyo, kwaye bakholelwa ukuba [ukufumana izithako zenkcubeko zeseli ezingabizi kakhulu njenge-insulin] yeyona ngxaki inkulu kwishishini, kwaye ishishini likwanayo impembelelo enkulu kwimozulu.
Ewe kunjalo, sijonge kwimakethi yamayeza abantu kunye nentengiso yeswekile, kodwa sifuna inqanawa enkulu ngakumbi ngenxa yokuba ngokufumana imvume yolawulo, udinga i-10 lezigidi zeedola ukwenza amaphepha, emva koko kufuneka wenze. Uqinisekile ukuba une-molecule elungileyo ekucocekeni okufanelekileyo, njl.
J: Konke malunga nokunyusa. Bendinenkampani yokufama izinambuzane [i-Millibeter, efunyenwe yi-AgriProtein [engasekhoyo ngoku] ngo-2019] iminyaka eli-10. Ke sijonge izinambuzane ezininzi ezahlukeneyo, kwaye eyona nto iphambili yayikukunyusa imveliso ngokuthembekileyo nangexabiso eliphantsi, kwaye uninzi lweenkampani zaphela zihamba neempukane zamajoni amnyama okanye iintshulube zokutya. Ewe, ngokuqinisekileyo, ungazikhulisa iimpukane zeziqhamo, kodwa kunzima ngokwenene ukuzikhulisa ngobuninzi ngendlela ephantsi nethembekileyo, kwaye ezinye izityalo zinokuvelisa iitoni ezili-10 ze-biomass yezinambuzane ngosuku.
JJ: Ngoko ke ezinye iimveliso zezinambuzane, iiprotheni zezinambuzane, i-lipids yezinambuzane, njl., zinokusetyenziswa ngokobugcisa kwikhonkco lexabiso lezinambuzane eziqhelekileyo, kodwa kwezinye iindawo, ngenxa yokuba yimveliso yofuzo, ayiyi kwamkelwa njengesondlo semfuyo.
Nangona kunjalo, zininzi izicelo zetekhnoloji ngaphandle kwekhonkco lokutya ezinokusebenzisa iiproteni kunye neelipids. Umzekelo, ukuba uvelisa igrisi yeshishini kwinqanaba lemizi-mveliso, akunamsebenzi nokuba i-lipid ivela kumthombo oguqulwe ngokwemfuza.
Ngokuphathelele umgquba [ilindle lezinambuzane], kufuneka silumke xa siwuhambisa emasimini kuba uneempawu zeGMO, ngoko ke siyawugalela kwibiochar.
DD: Kwisithuba sonyaka… besinomgca wokuzala ozinzileyo obonisa i-insulin yabantu kwizivuno eziphezulu kakhulu. Ngoku kufuneka sikhuphe iimolekyuli kwaye sinikeze iisampulu kubathengi bethu, kwaye emva koko sisebenze kunye nabathengi malunga nokuba yeyiphi iamolekyuli abayidingayo ngokulandelayo.
Ixesha lokuposa: Dec-25-2024